1. 911 (Emergency Services) — For any life-threatening situation, including a suspected overdose in progress. Call immediately; overdoses can be reversed if help arrives in time.
2. 988 Suicide & Crisis Lifeline — Call or text 988 for free, confidential, 24/7 support for anyone in emotional distress, suicidal crisis, or a substance use crisis; chat also available at [988lifeline.org](https://988lifeline.org). [samhsa](https://www.samhsa.gov/find-help/helplines)
3. SAMHSA National Helpline — 1-800-662-HELP (4357), TTY 800-487-4889. Free, confidential, 24/7/365 treatment referral and information service in English and Spanish for individuals and families facing substance use or mental health issues. You can also text your ZIP code to 435748 (HELP4U) (SAMHSA, USA.gov). [samhsa](https://www.samhsa.gov/find-help/helplines/national-helpline)
4. Never Use Alone — Overdose Prevention Hotline — 1-800-484-3731 or 1-877-696-1996, 24/7/365. Anyone about to use drugs alone can call and stay on the line with a peer specialist who will send emergency help if the caller becomes unresponsive. [neverusealone](https://neverusealone.com/)
5. Crisis Text Line — Text HOME to 741741 to reach a trained crisis counselor by text, 24/7, free and confidential.
6. National Poison Control — Poison Help Line — 1-800-222-1222, 24/7, free and confidential. Connects you to the poison center covering your area for any suspected poisoning, overdose question, or medication concern, whether or not it’s an emergency (Poison Control, HRSA Poison Help). [poison](https://www.poison.org/need-immediate-assistance)
7. Veterans Crisis Line — Dial 988, then press 1, or text 838255, or chat at [veteranscrisisline.net](https://veteranscrisisline.net). 24/7 support for veterans, service members, and their loved ones in crisis. [nami](https://www.nami.org/service-members-and-veterans/)
8. NAMI HelpLine — 1-800-950-6264 (Mon–Fri, 10am–10pm ET), or text “HelpLine” to 62640. National Alliance on Mental Illness is not a crisis line per se, but a good first call for guidance on navigating a mental health or co-occurring substance use crisis ([NAMI](https://helplinefaqs.nami.org/article/457)).
9. The Trevor Project (LGBTQ+ Youth Crisis Line) — 1-866-488-7386, or text START to 678-678, or chat at TheTrevorProject.org. 24/7/365, free and confidential — important to include since LGBTQ+ youth face disproportionately higher rates of substance use and suicide risk. [thetrevorproject](https://www.thetrevorproject.org/resources/guide/here-for-you-24-7-how-to-reach-out-to-the-trevor-project/)
10. Naloxone (Narcan) Access & Overdose Response Info — Link to a naloxone locator (e.g., NEXT Distro or your state health department’s finder tool) so visitors can find free naloxone near them and learn the signs of an overdose before an emergency happens — this belongs alongside the hotlines since minutes matter and having naloxone on hand can be the difference before 911 even arrives.
